Single protein could play crucial role in fighting Alzheimer’s

Increasing levels of a protein called SOX9 significantly enhances the cleaning ability of these astrocytes.

Scientists have identified a promising new mechanism through which the brain can activate its own support cells to clear harmful plaques linked to Alzheimer’s disease.

Researchers at Baylor College of Medicine found that this natural process can help remove toxic amyloid plaques from the brains of Alzheimer’s-affected mice while also preserving memory and cognitive function.

The breakthrough centers on specialized brain cells known as astrocytes. These cells, which normally support neurons, can be stimulated to actively clear toxic substances that accumulate during Alzheimer’s disease.

According to findings published in Nature Neuroscience, increasing levels of a protein called SOX9 significantly enhances the cleaning ability of these astrocytes.

The study suggests a potential new treatment approach that focuses on strengthening the brain’s own defense system to slow cognitive decline, rather than relying solely on external drug interventions.

Lead researcher Dong-Ju Choi explained that astrocytes play a critical role in maintaining brain communication and preserving memory.

However, their function changes with age, and scientists are still working to fully understand how these shifts contribute to neurodegenerative diseases.